tag:blogger.com,1999:blog-5714839940982963256.post6261254978308657922..comments2023-09-24T07:11:19.062-07:00Comments on Tourette_Turet_ Sendromu: SADECE BAŞARI ÖYKÜLERİ İLE BİLİM OLMAZ - İMPLANT UYGULAMALARI A.Şükran Demiralphttp://www.blogger.com/profile/00933510330057966078noreply@blogger.comBlogger2125tag:blogger.com,1999:blog-5714839940982963256.post-63958314490729931462019-05-28T01:02:33.425-07:002019-05-28T01:02:33.425-07:00Her geçen gün implant nasıl yapılır konu başlığı i...Her geçen gün <a href="https://www.mustafakerdogan.com/implant-nedir-nasil-yapilir-nevsehir-implant/" rel="nofollow"><strong>implant nasıl yapılır</strong></a> konu başlığı ile ilgili merak edilenler göz doldurmaktadır.lahana çorbasıhttps://www.blogger.com/profile/15276465544083455582noreply@blogger.comtag:blogger.com,1999:blog-5714839940982963256.post-60415334511239283252018-07-29T06:16:27.617-07:002018-07-29T06:16:27.617-07:00"JAMA Neurol. 2018 Mar 1;75(3):353-359. doi: ..."JAMA Neurol. 2018 Mar 1;75(3):353-359. doi: 10.1001/jamaneurol.2017.4317.<br /><br />Efficacy and Safety of Deep Brain Stimulation in Tourette Syndrome: <br /><br />The International Tourette Syndrome Deep Brain Stimulation Public Database and Registry.<br /><br />Martinez-Ramirez D1, Jimenez-Shahed J2, Leckman JF3, Porta M4, Servello D5, Meng FG6, Kuhn J7,8, Huys D7, Baldermann JC7, Foltynie T9, Hariz MI9,10, Joyce EM9, Zrinzo L9, Kefalopoulou Z9, Silburn P11, Coyne T11, Mogilner AY12, Pourfar MH12, Khandhar SM13, Auyeung M14, Ostrem JL15, Visser-Vandewalle V16, Welter ML17, Mallet L18,19,20, Karachi C21, Houeto JL22,23, Klassen BT24, Ackermans L25, Kaido T26,27, Temel Y28, Gross RE29, Walker HC30,31, Lozano AM32, Walter BL33,34,35, Mari Z36, Anderson WS36, Changizi BK37, Moro E38,39, Zauber SE40, Schrock LE41, Zhang JG42, Hu W1, Rizer K1, Monari EH1, Foote KD43,44, Malaty IA1, Deeb W1, Gunduz A45, Okun MS1,44.<br /><br />Author information<br /><br />Abstract<br /><br />IMPORTANCE:<br /><br />Collective evidence has strongly suggested that deep brain stimulation (DBS) is a promising therapy for Tourette syndrome.<br /><br />OBJECTIVE:<br />To assess the efficacy and safety of DBS in a multinational cohort of patients with Tourette syndrome.<br /><br />DESIGN, SETTING, AND PARTICIPANTS:<br />The prospective International Deep Brain Stimulation Database and Registry included 185 patients with medically refractory Tourette syndrome who underwent DBS implantation from January 1, 2012, to December 31, 2016, at 31 institutions in 10 countries worldwide.<br /><br />EXPOSURES:<br />Patients with medically refractory symptoms received DBS implantation in the centromedian thalamic region (93 of 163 [57.1%]), the anterior globus pallidus internus (41 of 163 [25.2%]), the posterior globus pallidus internus (25 of 163 [15.3%]), and the anterior limb of the internal capsule (4 of 163 [2.5%]).<br /><br />MAIN OUTCOMES AND MEASURES:<br />Scores on the Yale Global Tic Severity Scale and adverse events.<br /><br />RESULTS:<br />The International Deep Brain Stimulation Database and Registry enrolled 185 patients (of 171 with available data, 37 females and 134 males; mean [SD] age at surgery, 29.1 [10.8] years [range, 13-58 years]). Symptoms of obsessive-compulsive disorder were present in 97 of 151 patients (64.2%) and 32 of 148 (21.6%) had a history of self-injurious behavior. The mean (SD) total Yale Global Tic Severity Scale score improved from 75.01 (18.36) at baseline to 41.19 (20.00) at 1 year after DBS implantation (P < .001). The mean (SD) motor tic subscore improved from 21.00 (3.72) at baseline to 12.91 (5.78) after 1 year (P < .001), and the mean (SD) phonic tic subscore improved from 16.82 (6.56) at baseline to 9.63 (6.99) at 1 year (P < .001). The overall adverse event rate was 35.4% (56 of 158 patients), with intracranial hemorrhage occurring in 2 patients (1.3%), infection in 4 patients with 5 events (3.2%), and lead explantation in 1 patient (0.6%). The most common stimulation-induced adverse effects were dysarthria (10 [6.3%]) and paresthesia (13 [8.2%]).<br /><br />CONCLUSIONS AND RELEVANCE:<br />Deep brain stimulation was associated with symptomatic improvement in patients with Tourette syndrome but also with important adverse events. A publicly available website on outcomes of DBS in patients with Tourette syndrome has been provided."<br /><br />Kaynak: https://www.ncbi.nlm.nih.gov/pubmed/29340590A.Şükran Demiralphttps://www.blogger.com/profile/00933510330057966078noreply@blogger.com